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KMID : 1114620130100020145
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Journal of the Korean Society for Breast Screening
2013 Volume.10 No. 2 p.145 ~ p.152
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Differentiation of Breast Tissues by Resistive Force Induced by Friction of Fine Needle
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Paik Moon-Hee
Song Kyung-Sup
Kim Hak-Hee
Gong Gyung-Yub
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Abstract
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Purpose: The purpose of this study was to evaluate the possibility of differentiating breast lesions on the basis of tissue hardness.
Materials and Methods: The tissue hardness was measured by friction resistive forces (FRFs) induced by vertical to-and-fro movements of 20 G Franseen needle in 112 surgical breast specimens. A pressure sensor (Nano 17 force torque sensor transducer, ATI industrial automation, NC, USA) was attached to the proximal end of the 20 G Franseen fine needle, and the FRFs were measured. Mean FRFs were compared in the four different pathologically-proven breast tissue groups: fat (n=11), normal glandular tissue (n=13), benign lesion (n=39), malignant lesion (n=49). Statistically one-way ANOVA test and receiver operating characteristics curve analysis were performed.
Results: The difference in the Mean FRFs of the four different breast tissue groups were statistically different (P<0.0001). The Mean FRFs were as follows: fat 260.3 ± 163.8 Newton(N), normal glandular tissue 565.7 ± 264.0 N, benign lesion 1143.0 ± 852.3 N, malignant lesion 2187.7 ± 1263.3 N. Cutoff value, sensitivity, specificity and accuracy between the groups were as follows: 431.6 N, 69.2%, 90.9%, 79.2% between the fat and normal glandular tissue, 680.3 N, 61.5%, 61.5%, 63.5% between normal glandular tissue and benign lesion, 1364.1 N, 79.6%, 71.8%, 75% between the benign and malignant lesions.
Conclusion: The tissue hardnesses as measured by fine needle movements show a statistically significant difference among the different breast tissue groups. The measurement of FRFs during the fine needle aspiration biopsy in breast tissue may provide useful, additive information that may facilitate the differentiation of malignant and benign lesions.
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KEYWORD
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Tissue hardness, Resistive force, Breast
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